Description

5-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[b]thiophene is a high-purity boronic ester derivative, a critical building block in modern synthetic chemistry. Its value lies in enabling efficient, selective cross-coupling reactions, which are fundamental for constructing complex molecular architectures. This advanced intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries, particularly for the development of novel active ingredients and functional organic compounds.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing fluorinated benzo[b]thiophene derivatives, which are scaffolds in drug discovery for various therapeutic areas.
• Agrochemical Synthesis: Used to incorporate the benzo[b]thiophene moiety into novel crop protection agents, leveraging the potential biological activity of the fluorinated heterocycle.
• Organic Electronic Materials: Serves as a building block for creating conjugated polymers and small molecules for applications in OLEDs, OFETs, and other optoelectronic devices.
• Chemical Research & Development: An invaluable tool for medicinal and process chemists exploring new chemical space and optimizing synthetic routes in R&D laboratories.
• Ligand and Catalyst Development: Can be utilized to synthesize novel bidentate or polydentate ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	5-Fluoro-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-Benzo[B]Thiophene
CAS No.	958451-93-9
Molecular Formula	C₁₄H₁₆BFO₂S
Molecular Weight	278.15 g/mol
Synonyms	5-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-benzothiophene; 2-(5-Fluorobenzo[b]thiophen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Benzo[b]thiophene-2-boronic acid, 5-fluoro-, pinacol ester; 5-Fluoro-1-benzothiophene-2-boronic acid pinacol ester; 958451-93-9; 5-Fluoro-2-(pinacolatoboryl)benzo[b]thiophene
EINECS	Contact for details

Quality Control

Every batch of 5-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[b]thiophene is manufactured and tested under strict quality management systems. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency meet the exacting standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.