Description

3-Fluoro-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzamide is a high-purity boronic ester derivative, a crucial building block in modern synthetic organic chemistry. Its value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing fluorinated biaryl motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that leverage the stability and reactivity of the boronic ester group.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics, where precise molecular architecture is critical.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and labeled compounds for biochemical assays and diagnostic applications.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura cross-coupling to form carbon-carbon bonds under mild conditions.
• Library Synthesis for Drug Discovery: A valuable reagent for the parallel and combinatorial synthesis of diverse compound libraries for high-throughput screening.

Basic Information

Item	Detail
Product Name	3-Fluoro-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzamide
CAS No.	957346-54-2
Molecular Formula	C13H17BFNO3
Molecular Weight	265.09 g/mol
Synonyms	4-Carbamoyl-2-fluorophenylboronic acid pinacol ester; 2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide; 3-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-fluorobenzamide; 3-Fluoro-4-(pinacolatoboryl)benzamide; B-(4-Carbamoyl-2-fluorophenyl)boronic acid pinacol ester; 957346-54-2; AMBZ1077
EINECS	Contact for details

Quality Control

Our 3-Fluoro-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzamide is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal stability and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.