Description

Pyridine, 2-Ethoxy-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a specialized organoboron building block of significant importance in modern synthetic chemistry. This compound matters for its role as a key intermediate in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl and heterobiaryl structures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Critical for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing complex pyridine and biaryl motifs.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides requiring specific aryl-aryl linkages.
• Material Science Research: Serves as a precursor for organic electronic materials, such as ligands for OLEDs and charge-transport materials.
• Cross-Coupling Reactions: A dedicated boronic ester pinacol reagent for palladium-catalyzed Suzuki-Miyaura couplings with various aryl/heteroaryl halides.
• Chemical Biology & Medicinal Chemistry: Enables the late-stage functionalization and diversification of complex molecules in library synthesis for screening.
• Ligand and Catalyst Development: Used to construct sophisticated nitrogen-containing ligands for transition metal catalysis.

Basic Information

Item	Details
Product Name	Pyridine, 2-Ethoxy-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	957346-47-3
Molecular Formula	C15H24BNO3
Molecular Weight	277.17 g/mol
Synonyms	2-Ethoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 4-Pinacolatoboryl-2-ethoxypyridine; 2-Ethoxy-4-(pinacolatoboryl)pyridine; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-ethoxypyridine; 2-Ethoxy-4-pyridineboronic acid pinacol ester; 4-Borono-2-ethoxypyridine pinacol ester; (2-Ethoxypyridin-4-yl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our production of Pyridine, 2-Ethoxy-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials are characterized by NMR (1H, 13C, 11B), HPLC, and GC analysis to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.