Description

1H-Isoindol-1-One, 7-Fluoro-2,3-Dihydro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-value pharmaceutical intermediate and advanced building block featuring a fused isoindolone core. This compound is specifically engineered for Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern synthetic chemistry. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the efficient construction of complex, fluorinated heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and oncology.
• Suzuki-Miyaura Cross-Coupling: The boronic ester pinacol group enables efficient palladium-catalyzed coupling with aryl/heteroaryl halides, facilitating rapid library synthesis for drug discovery.
• Agrochemical Research: Used in the development of new herbicides and fungicides, where the fluorinated isoindolone structure can impart desirable biological activity and metabolic stability.
• Material Science Precursor: Serves as a specialized monomer or precursor for the development of organic electronic materials and advanced polymers.
• Chemical Biology Probes: Employed in the synthesis of fluorinated probes and tags for studying biological mechanisms and protein interactions.

Basic Information

Product Name	1H-Isoindol-1-One, 7-Fluoro-2,3-Dihydro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	957346-40-6
Molecular Formula	C14H17BFO3
Molecular Weight	263.10 g/mol
Synonyms	7-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-isoindol-1-one; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-7-fluoro-2,3-dihydro-1H-isoindol-1-one; 7-Fluoro-2,3-dihydro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-isoindol-1-one; 7-Fluoro-5-(pinacolatoboryl)-2,3-dihydro-1H-isoindol-1-one; 5-Borono-7-fluoro-2,3-dihydro-1H-isoindol-1-one pinacol ester; CAS 957346-40-6; Fluorinated Isoindolone Boronic Ester.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch is characterized using advanced analytical techniques including NMR (1H, 13C, 19F, 11B), HPLC, and LC-MS to ensure structural identity and high chemical purity. Certificates of Analysis (COA) with full analytical data are provided for each lot, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (nitrogen or argon) for long-term storage to maintain stability and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.