Description

4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Thiophene-2-Carboxamide is a high-value organoboron building block, specifically a pinacol boronate ester derivative of a thiophene carboxamide. This compound is critical for modern synthetic chemistry, enabling efficient carbon-carbon bond formation via cross-coupling reactions. It is primarily utilized by research scientists and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing complex drug candidates, particularly those containing thiophene-based heterocycles.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, where the thiophene moiety imparts specific biological activity.
• Material Science Research: Serves as a monomer or building block for creating conjugated polymers and organic electronic materials like OLEDs and organic semiconductors.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes and activity-based protein profiling (ABPP) reagents due to its reactive boronate handle.
• Academic & Contract Research: Essential for methodological development in organic synthesis and catalysis studies within university and CRO laboratories.

Basic Information

Product Name	4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Thiophene-2-Carboxamide
CAS No.	957345-71-0
Molecular Formula	C11H16BNO3S
Molecular Weight	253.13 g/mol
Synonyms	2-Carbamoylthiophene-4-boronic acid pinacol ester; Thiophene-2-carboxamide, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 4-(Pinacolatoboryl)thiophene-2-carboxamide; 4-Borono-2-carbamoylthiophene pinacol ester; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-thiophenecarboxamide
EINECS	Contact for details

Quality Control

Our 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Thiophene-2-Carboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR (1H, 13C, 11B), and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.