Description

4-Carbamoyl-3,5-Difluorobenzeneboronic Acid Pinacol Ester, 96% is a high-purity boronic ester derivative, a critical building block in modern synthetic organic chemistry. Its primary value lies in enabling the precise construction of complex molecules through cross-coupling reactions, particularly the Suzuki-Miyaura reaction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing new active ingredients. The pinacol ester group enhances stability, making it a reliable and convenient reagent for demanding synthetic applications.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing difluorophenyl and carboxamide motifs for oncology, CNS, and metabolic disease targets.
• Agrochemical Synthesis: Used in constructing novel herbicides, fungicides, and insecticides where the difluorobenzene core contributes to biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or building block for creating advanced organic materials, such as polymers for organic electronics (OLEDs, OFETs) and metal-organic frameworks (MOFs).
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for catalysis and molecular recognition studies.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and inhibitors for studying enzyme function and biological pathways.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	4-Carbamoyl-3,5-Difluorobenzeneboronic Acid Pinacol Ester, 96%
CAS No.	957345-69-6
Molecular Formula	C13H16BF2NO3
Molecular Weight	283.08 g/mol
Synonyms	3,5-Difluoro-4-(aminocarbonyl)benzeneboronic Acid Pinacol Ester; 4-Carbamoyl-3,5-difluorophenylboronic Acid Pinacol Ester; (4-Carbamoyl-3,5-difluorophenyl)boronic Acid Pinacol Ester; 3,5-Difluoro-4-carbamoylbenzeneboronic Acid Pinacol Ester; Pinacol (4-Carbamoyl-3,5-difluorophenyl)boronate; 957345-69-6; Boronic acid, B-[4-(aminocarbonyl)-3,5-difluorophenyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 4-Carbamoyl-3,5-Difluorobenzeneboronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. The product undergoes comprehensive analytical testing, including HPLC, NMR (1H, 13C, 19F, 11B), and mass spectrometry, to confirm identity and assay. A Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and may benefit from storage under an inert atmosphere or with desiccant to maintain purity and prevent hydrolysis.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 96.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.