Description

2-Fluoro-4-Iodo-6-(Trifluoromethyl)Pyridine is a high-value, multi-halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. Its unique structure, featuring fluorine, iodine, and trifluoromethyl substituents, makes it an indispensable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and CNS drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the fluorine and trifluoromethyl groups.
• Ligand & Catalyst Development: Serves as a precursor for sophisticated ligands in transition metal catalysis and organocatalysis, enabling novel synthetic transformations.
• Material Science Research: Building block for organic electronic materials, such as OLEDs and semiconductors, where halogenated pyridines modify charge transport properties.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create complex biaryl systems.
• Fluorine Chemistry & Radiochemistry: Useful in 18F-radiolabeling precursor studies and as a stable analog in metabolic pathway investigations.

Basic Information

Product Name	2-Fluoro-4-Iodo-6-(Trifluoromethyl)Pyridine
CAS No.	957345-37-8
Molecular Formula	C6H2F4IN
Molecular Weight	306.98 g/mol
Synonyms	4-Iodo-2-fluoro-6-(trifluoromethyl)pyridine; 2-Fluoro-4-iodo-6-trifluoromethylpyridine; 6-(Trifluoromethyl)-2-fluoro-4-iodopyridine; Pyridine, 2-fluoro-4-iodo-6-(trifluoromethyl)-; 957345-37-8; FC-4I-6TFMP; 2-F-4-I-6-CF3-Py
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-4-Iodo-6-(Trifluoromethyl)Pyridine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure consistency and reliability for your critical synthesis work. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by advanced chromatographic and spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Any single impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.