Description

2-Fluoro-3-Iodo-6-(Trifluoromethyl)Pyridine is a highly functionalized pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique combination of fluorine, iodine, and trifluoromethyl substituents makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, catalyst development, and material science.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of fluorine.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of advanced organic electronic materials, such as OLED components and liquid crystals.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira).
• Fluorine Chemistry Studies: A valuable compound for investigating structure-activity relationships (SAR) and the effects of fluorination.

Basic Information

Product Name	2-Fluoro-3-Iodo-6-(Trifluoromethyl)Pyridine
CAS No.	957345-34-5
Molecular Formula	C6H2F4IN
Molecular Weight	306.98 g/mol
Synonyms	2-Fluoro-3-iodo-6-(trifluoromethyl)pyridine; 6-(Trifluoromethyl)-2-fluoro-3-iodopyridine; 3-Iodo-2-fluoro-6-(trifluoromethyl)pyridine; Pyridine, 2-fluoro-3-iodo-6-(trifluoromethyl)-; 2-Fluoro-3-iodo-6-trifluoromethylpyridine
EINECS	Contact for details

Quality Control

Our 2-Fluoro-3-Iodo-6-(Trifluoromethyl)Pyridine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and industry best practices for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is light-sensitive (store away from light) and should be handled under an inert atmosphere when appropriate for prolonged use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/GC)	Conforms
Identification (NMR)	Conforms
Assay (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.