Description

3-Cyclopropyl-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2H-Pyrazole is a high-purity, advanced pharmaceutical intermediate featuring a pyrazole core functionalized with a cyclopropyl group and a pinacol boronate ester. This compound is a critical building block in modern medicinal chemistry, enabling efficient cross-coupling reactions for the synthesis of complex bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of new therapeutic agents, particularly in oncology and central nervous system (CNS) drug candidates.

Application

• Suzuki-Miyaura Cross-Coupling Reagent: A key boron-containing reagent for constructing carbon-carbon bonds in the synthesis of novel drug candidates and agrochemicals.
• Pharmaceutical Intermediate: Serves as a versatile scaffold for the development of small-molecule inhibitors targeting various enzymes and receptors.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to improve potency and pharmacokinetic properties.
• Chemical Biology Probes: Employed in the synthesis of molecular probes for studying biological pathways and target engagement.
• Agrochemical Development: Acts as a precursor for creating new active ingredients with potential herbicidal or insecticidal activity.
• Material Science: Investigated as a monomer or precursor for functional polymers and advanced organic electronic materials.

Basic Information

Product Name	3-Cyclopropyl-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2H-Pyrazole
CAS No.	957345-32-3
Molecular Formula	C11H19BN2O2
Molecular Weight	222.10 g/mol
Synonyms	3-Cyclopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 3-Cyclopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-pyrazole; 3-Cyclopropyl-1H-pyrazole-4-boronic acid pinacol ester; 3-Cyclopropyl-4-(pinacolboranyl)-1H-pyrazole; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-cyclopropyl-1H-pyrazole; 3-Cyclopropyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 3-Cyclopropyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole
EINECS	Contact for details

Quality Control

Our 3-Cyclopropyl-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2H-Pyrazole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high standards, such as pharmaceutical R&D and GLP-compliant studies.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The container should be kept tightly sealed under an inert atmosphere to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.