Description

2-(4-Morpholino)Pyrimidine-5-Boronic Acid Pinacol Ester is a high-value boronic ester derivative, a crucial building block in modern synthetic chemistry. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to synthesize novel active ingredients and advanced intermediates. The CAS number for this product is 957198-30-0.

Application

This versatile boronic ester is a key intermediate in the synthesis of complex organic molecules. Its primary applications include:

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and other small-molecule drug discovery programs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the morpholino-pyrimidine scaffold.
• Material Science Research: Serves as a precursor for creating organic electronic materials, ligands for catalysts, and other functionalized molecules.
• Chemical Biology Probes: Employed in the development of tool compounds and probes for studying biological pathways and target validation.
• Cross-Coupling Reactions: Specifically designed for use in palladium-catalyzed Suzuki-Miyaura cross-coupling to introduce the 2-(4-morpholino)pyrimidin-5-yl moiety into target molecules.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds at various scales.

Basic Information

Product Name	2-(4-Morpholino)Pyrimidine-5-Boronic Acid Pinacol Ester
CAS No.	957198-30-0
Molecular Formula	C15H22BN3O3
Molecular Weight	303.17 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-morpholinopyrimidine; 2-Morpholin-4-ylpyrimidine-5-boronic acid pinacol ester; 2-Morpholinopyrimidine-5-boronic acid pinacol ester; 2-(Morpholin-4-yl)pyrimidine-5-boronic acid pinacol ester; 2-(4-Morpholinyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; 957198-30-0; 2-Morpholin-4-yl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine
EINECS	Contact for details

Quality Control

Our 2-(4-Morpholino)Pyrimidine-5-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance in sensitive cross-coupling applications. Certificates of Analysis (COA) with detailed specifications are provided for each lot to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. For long-term storage, consider storing under an inert gas in a freezer (-20°C).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.