Description

(R)-tert-Butyl 8-(3,5-Difluorophenyl)-9-(2-Ethoxy-2-Oxoethyl)-10-Oxo-6,9-Diazaspiro[4.5]Decane-6-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and diazepane core structure. This compound is of significant value for its role as a key chiral building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring high stereochemical purity. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of new drugs, especially within the fields of central nervous system (CNS) and metabolic disorder treatments.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral precursor in the multi-step synthesis of proprietary drug candidates.
• API Development: Used in research and development for constructing complex molecular architectures in new chemical entities (NCEs).
• Preclinical & Clinical Research: Supplied to laboratories for pharmacological studies, toxicity testing, and formulation development.
• Process Chemistry: Employed in route scouting and optimization for scalable GMP manufacturing of target molecules.
• Chemical Biology: Utilized as a tool compound or scaffold for probing biological pathways and target engagement.
• Custom Synthesis: A starting point for contract research organizations (CROs) and CDMOs offering bespoke synthesis services.

Basic Information

Product Name	(R)-tert-Butyl 8-(3,5-Difluorophenyl)-9-(2-Ethoxy-2-Oxoethyl)-10-Oxo-6,9-Diazaspiro[4.5]Decane-6-Carboxylate
CAS No.	957122-11-1
Molecular Formula	C23H30F2N2O5
Molecular Weight	452.50 g/mol
Synonyms	(R)-tert-Butyl 8-(3,5-difluorophenyl)-9-(2-ethoxy-2-oxoethyl)-10-oxo-6,9-diazaspiro[4.5]decane-6-carboxylate; 6,9-Diazaspiro[4.5]decane-6-carboxylic acid, 8-(3,5-difluorophenyl)-9-(2-ethoxy-2-oxoethyl)-10-oxo-, 1,1-dimethylethyl ester, (6R)-; (6R)-8-(3,5-Difluorophenyl)-9-(2-ethoxy-2-oxoethyl)-10-oxo-6,9-diazaspiro[4.5]decane-6-carboxylic acid tert-butyl ester; tert-Butyl (6R)-8-(3,5-difluorophenyl)-9-(2-ethoxy-2-oxoethyl)-10-oxo-6,9-diazaspiro[4.5]decane-6-carboxylate; CAS 957122-11-1
EINECS	Contact for details

Quality Control

Our (R)-tert-Butyl 8-(3,5-Difluorophenyl)-9-(2-Ethoxy-2-Oxoethyl)-10-Oxo-6,9-Diazaspiro[4.5]Decane-6-Carboxylate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure enantiomeric purity and comprehensive impurity profiling. Certificates of Analysis (COA) detailing identity, purity, and related substances are provided and available upon request, supporting your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.