Description

Methyl 3-Borono-5-Chlorobenzoate is a high-value, multi-functional chemical building block that combines a boronic acid ester group with a chlorinated aromatic ester. This compound is critical for facilitating complex organic transformations, particularly in the synthesis of advanced pharmaceutical intermediates and functional materials. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications in cross-coupling reactions and medicinal chemistry.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a key arylboronate ester coupling partner for the synthesis of biaryl structures, a common motif in active pharmaceutical ingredients (APIs).
• Pharmaceutical Intermediate Synthesis: Used in the research and development of novel drug candidates, especially those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Active Ingredient Development: Employed in the creation of new herbicides and fungicides where the chlorinated biaryl scaffold is beneficial.
• Ligand and Catalyst Preparation: Acts as a precursor for synthesizing specialized ligands used in homogeneous catalysis.
• Material Science Research: Utilized in the development of organic electronic materials and metal-organic frameworks (MOFs) due to its functional handle for further modification.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	Methyl 3-Borono-5-Chlorobenzoate
CAS No.	957120-26-2
Molecular Formula	C8H8BClO4
Molecular Weight	214.41 g/mol
Synonyms	(5-Chloro-3-(methoxycarbonyl)phenyl)boronic acid; Methyl 5-chloro-3-boronobenzoate; 3-Borono-5-chlorobenzoic acid methyl ester; Benzoic acid, 3-borono-5-chloro-, methyl ester; 5-Chloro-3-carbomethoxyphenylboronic acid; CAS 957120-26-2
EINECS	Contact for details

Quality Control

Every batch of Methyl 3-Borono-5-Chlorobenzoate is produced and analyzed under strict quality management protocols to ensure consistency and reliability for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality systems are designed to support cGMP and ISO standards for customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.