Description

2-(2-(Bromomethyl)-4-(Trifluoromethoxy)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-value, multi-functional boronic ester building block designed for advanced organic synthesis. Its molecular architecture, featuring both a reactive bromomethyl handle and a stable boronate ester, makes it a critical intermediate for constructing complex molecules in pharmaceutical and agrochemical research. This compound is primarily utilized by R&D chemists and process development scientists in the life sciences sector for applications such as Suzuki-Miyaura cross-coupling and further functionalization.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing trifluoromethoxy and aryl-boronate motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific aryl-boron chemistry.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronic ester partner for forming carbon-carbon bonds to create biaryl structures, a fundamental reaction in medicinal chemistry.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, where its structure can be incorporated into conjugated systems.
• Chemical Biology & Probe Development: Useful for creating molecular probes and tags due to its ability to undergo further selective transformations.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific custom synthesis projects.

Basic Information

Product Name	2-(2-(Bromomethyl)-4-(Trifluoromethoxy)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	957066-13-6
Molecular Formula	C15H19BBrF3O3
Molecular Weight	395.02 g/mol
Synonyms	4,4,5,5-Tetramethyl-2-[2-(bromomethyl)-4-(trifluoromethoxy)phenyl]-1,3,2-dioxaborolane; 2-(2-Bromomethyl-4-trifluoromethoxyphenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane; Pinacol [2-(bromomethyl)-4-(trifluoromethoxy)phenyl]boronate; [2-(Bromomethyl)-4-(trifluoromethoxy)phenyl]boronic acid pinacol ester; Bromomethyl-trifluoromethoxyphenyl pinacol boronate; 957066-13-6; CAS 957066-13-6
EINECS	Contact for details

Quality Control

Our 2-(2-(Bromomethyl)-4-(Trifluoromethoxy)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with the standards expected for GMP-intermediate and high-purity research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (GC)	≥96.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.