Description

5-Borono-4-Chloro-2-Methoxybenzoic Acid is a high-value, multifunctional aromatic boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its unique structure, featuring both a boronic acid pinacol ester precursor and a carboxylic acid group, makes it an indispensable reagent for constructing complex molecules via cross-coupling and other advanced transformations. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel biaryl compounds with potential therapeutic activity.
• Agrochemical Research: Used in the discovery and synthesis of new herbicides, fungicides, and insecticides that require specific halogenated and functionalized aromatic scaffolds.
• Material Science: Serves as a monomer or functionalizing agent in the development of organic electronic materials, such as polymers for OLEDs or sensors.
• Chemical Biology & Proteomics: Utilized as a handle for bioconjugation or as a component in designing enzyme inhibitors and molecular probes.
• Academic & Process R&D: Employed in methodological studies and scale-up process development for complex organic syntheses.
• Ligand Synthesis: Acts as a starting material for creating sophisticated ligands used in catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	5-Borono-4-Chloro-2-Methoxybenzoic Acid
CAS No.	957066-09-0
Molecular Formula	C8H8BClO5
Molecular Weight	230.41 g/mol
Synonyms	4-Chloro-2-methoxy-5-boronobenzoic acid; 5-Borono-4-chloro-2-methoxybenzoic acid; 4-Chloro-2-methoxy-5-boronobenzoic acid; Benzoic acid, 5-borono-4-chloro-2-methoxy-; 4-Chloro-2-methoxy-5-boronobenzoic acid pinacol ester (common precursor); 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-chloro-2-methoxybenzoic acid (protected form); 4-Chloro-2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid
EINECS	Contact for details

Quality Control

Our 5-Borono-4-Chloro-2-Methoxybenzoic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay (HPLC), identity confirmation (IR, NMR), and impurity profiles. While typically supplied as a high-purity R&D grade, we can discuss custom synthesis to meet specific project requirements, including adherence to ICH guidelines for impurity identification.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions, such as in a glovebox or under an inert atmosphere, for long-term storage or when opening a new container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥95.0%
Purity (HPLC, Area %)	≥97.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.