Description

n-Methoxy-n-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzamide is a high-value, multi-functional chemical intermediate that combines a protected boronic ester with a Weinreb amide moiety. This unique structure makes it a critical building block for the efficient synthesis of complex molecules, particularly ketones, via chemoselective transformations. It is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for constructing novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific aryl ketone structures.
• Material Science: Serves as a building block for creating advanced organic materials, such as ligands for catalysts or monomers for specialty polymers.
• Cross-Coupling Reactions: The pinacol boronate ester group enables efficient Suzuki-Miyaura cross-coupling for biaryl bond formation.
• Weinreb Amide Chemistry: The N-methoxy-N-methylamide group allows for controlled nucleophilic addition to yield ketones without over-addition, a staple in complex organic synthesis.
• Chemical Research & Development: An essential tool in medicinal chemistry and process chemistry for exploring new synthetic routes and optimizing lead compounds.

Basic Information

Product Name	n-Methoxy-n-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzamide
CAS No.	957061-17-5
Molecular Formula	C16H24BNO5
Molecular Weight	321.18 g/mol
Synonyms	3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-methoxy-N-methylbenzamide; N-Methoxy-N-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid N-methoxy-N-methylamide; 3-(Pinacolatoboryl)-N-methoxy-N-methylbenzamide; 3-Weinreb Amido Phenylboronic Acid Pinacol Ester; Benzamide, N-methoxy-N-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
EINECS	Contact for details

Quality Control

Our n-Methoxy-n-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzamide is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and scale-up applications. A detailed Certificate of Analysis (COA) is provided with each shipment, guaranteeing traceability and consistent quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.