Description

(4-(2-Hydroxyethyl)Piperazin-1-Yl)(3-Boronophenyl)Methanone, Hcl is a high-purity, advanced pharmaceutical intermediate featuring a unique boronic acid functional group. This compound is valued for its role as a key building block in modern medicinal chemistry, particularly in the development of protease inhibitors and other targeted therapeutics. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the synthesis of novel active pharmaceutical ingredients (APIs) and bioconjugates.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of boron-containing drug candidates, especially protease inhibitors for treating conditions like cancer and viral infections.
• Bioconjugation & Probe Development: Used in creating affinity probes, sensors, and diagnostic agents that leverage the boronic acid moiety for selective binding to diols and sugars.
• Medicinal Chemistry Research: Serves as a versatile scaffold in drug discovery programs for structure-activity relationship (SAR) studies and lead optimization.
• Chemical Biology: Employed in the development of tools for studying enzyme mechanisms and cellular processes.
• Material Science: Potential use in the synthesis of functionalized polymers and advanced materials with specific chemical recognition properties.

Basic Information

Product Name	(4-(2-Hydroxyethyl)Piperazin-1-Yl)(3-Boronophenyl)Methanone, Hydrochloride
CAS No.	957060-95-6
Molecular Formula	C13H18BN2O3·HCl
Molecular Weight	296.56 g/mol (Free base)
Synonyms	1-(3-Boronobenzoyl)-4-(2-hydroxyethyl)piperazine hydrochloride; 3-[(4-(2-Hydroxyethyl)piperazine-1-carbonyl]phenylboronic acid hydrochloride; 3-Borono-N-[2-(4-piperazinyl)ethyl]benzamide hydrochloride; B-3-[(4-(2-Hydroxyethyl)-1-piperazinyl]carbonyl]benzeneboronic acid HCl; (3-Boronophenyl)[4-(2-hydroxyethyl)-1-piperazinyl]methanone hydrochloride
EINECS	Contact for details

Quality Control

Every batch of (4-(2-Hydroxyethyl)Piperazin-1-Yl)(3-Boronophenyl)Methanone, Hcl is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and conformity to agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.