Description

2-(2-(Bromomethyl)-4-Chlorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-value organoboron building block, specifically a boronic ester, designed for advanced synthetic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern pharmaceutical and agrochemical development. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries who require reliable, high-purity intermediates for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for constructing biaryl and heterobiaryl scaffolds common in drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific chlorinated and brominated aromatic structures.
• Material Science Research: Serves as a precursor for creating novel organic electronic materials, such as those used in OLEDs and organic photovoltaics, where the boronate ester functionality is key.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and tags for studying biological processes due to its reactivity in palladium-catalyzed transformations.
• Cross-Coupling Reactions: Primarily utilized in Suzuki-Miyaura cross-coupling to introduce the (2-bromomethyl)-4-chlorophenyl moiety into target molecules with high efficiency and selectivity.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2-(2-(Bromomethyl)-4-Chlorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	957034-64-9
Molecular Formula	C13H17BBrClO2
Molecular Weight	330.44 g/mol
Synonyms	4-Chloro-2-(bromomethyl)phenylboronic acid pinacol ester; (2-Bromomethyl-4-chlorophenyl)boronic acid pinacol ester; 2-(2-Bromomethyl-4-chlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 1-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(bromomethyl)benzene; PINACOL (2-(BROMOMETHYL)-4-CHLOROPHENYL)BORONATE; 2-(Bromomethyl)-4-chlorobenzeneboronic acid pinacol ester; CAS 957034-64-9
EINECS	Contact for details

Quality Control

Every batch of 2-(2-(Bromomethyl)-4-Chlorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured and analyzed under strict quality management protocols to ensure consistency and reliability for critical synthetic applications. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with exacting industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0% (Area %)
Purity (HPLC)	≥95.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.