Description

tert-Butyl 7-Hydroxy-4-oxospiro[chroman-2,4'-piperidine]-1'-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic molecular architecture. This compound is of significant value for its role as a critical building block in the synthesis of novel therapeutic agents, particularly within medicinal chemistry research and development. It is primarily sought after by pharmaceutical companies, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of central nervous system (CNS) and other bioactive small molecules.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates, particularly for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used as a core scaffold or building block for structure-activity relationship (SAR) studies and lead optimization programs.
• Protease Inhibitor Synthesis: The spirocyclic piperidine structure is valuable in constructing molecules that target various protease enzymes.
• Chemical Biology Probes: Utilized in the development of tool compounds for studying biological pathways and target validation.
• Custom Synthesis: Serves as a starting material for contract manufacturing organizations (CMOs) producing bespoke APIs and advanced intermediates.
• Academic Research: Employed in university and institutional labs for exploratory synthetic chemistry and pharmacology projects.

Basic Information

Product Name	tert-Butyl 7-Hydroxy-4-oxospiro[chroman-2,4'-piperidine]-1'-carboxylate
CAS No.	956605-22-4
Molecular Formula	C18H23NO5
Molecular Weight	333.38 g/mol
Synonyms	1'-Boc-7-hydroxy-4-oxospiro[chroman-2,4'-piperidine]; 7-Hydroxy-4-oxospiro[chroman-2,4'-piperidine]-1'-carboxylic acid tert-butyl ester; tert-Butyl 7-hydroxy-4-oxo-1,4-dihydrospiro[chroman-2,4'-piperidine]-1'-carboxylate; 1,4-Dihydrospiro[chroman-2,4'-piperidine]-1'-carboxylic acid, 7-hydroxy-4-oxo-, 1,1-dimethylethyl ester; Boc-protected 7-hydroxy-4-oxospiro[chroman-2,4'-piperidine]; Spiro[chroman-2,4'-piperidine] intermediate
EINECS	Contact for details

Quality Control

Our tert-Butyl 7-Hydroxy-4-oxospiro[chroman-2,4'-piperidine]-1'-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and pre-clinical development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive). Keep the container tightly sealed under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.