Description

2H-Pyrrolo[2,3-B]Pyridin-2-One, 4-Fluoro-1,3-Dihydro- is a high-value fluorinated heterocyclic building block, specifically a 4-fluoro derivative of the pyrrolopyridinone scaffold. This compound is critical for medicinal chemistry research and development, enabling the synthesis of novel bioactive molecules. It is primarily sought by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of new therapeutic agents, particularly in oncology and CNS disorders.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the development of novel small-molecule drugs.
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies and lead optimization programs due to its privileged heterocyclic structure.
• Kinase Inhibitor Development: The pyrrolopyridinone core is a common motif in kinase inhibitors, making this fluorinated derivative valuable for targeting specific enzyme isoforms.
• Chemical Biology Probes: Employed in the synthesis of tool compounds for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: A critical starting material for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client pipelines.
• Library Synthesis: Used to create focused chemical libraries for high-throughput screening in drug discovery campaigns.

Basic Information

Item	Detail
Product Name	2H-Pyrrolo[2,3-B]Pyridin-2-One, 4-Fluoro-1,3-Dihydro-
CAS No.	956460-93-8
Molecular Formula	C7H5FN2O
Molecular Weight	152.13 g/mol
Synonyms	4-Fluoro-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one; 4-Fluoro-2H-pyrrolo[2,3-b]pyridin-2-one; 4-Fluoro-1,3-dihydropyrrolo[2,3-b]pyridin-2-one; 4-Fluoro-2-oxo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine; 4-Fluoro-1H-pyrrolo[2,3-b]pyridin-2(3H)-one; Fluorinated Pyrrolopyridinone; 4-F-PPO
EINECS	Contact for details

Quality Control

Every batch of our 2H-Pyrrolo[2,3-B]Pyridin-2-One, 4-Fluoro-1,3-Dihydro- undergoes rigorous analytical testing to ensure it meets the stringent purity requirements for pharmaceutical R&D. Our quality systems are designed to guarantee batch-to-batch consistency and traceability. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.