Description

Methyl 2-(2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)phenyl)acetate is a high-value boronic ester derivative, a crucial building block in modern synthetic organic chemistry. Its primary value lies in its role as a protected boronic acid intermediate, enabling precise and efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to construct complex molecular architectures for active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for constructing biaryl and heterobiaryl structures common in drug molecules.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific aromatic coupling steps.
• Material Science Research: Serves as a monomer or building block for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Suzuki-Miyaura Cross-Coupling: The primary application is as a stable, air-handleable boronate reagent for palladium-catalyzed coupling with aryl or vinyl halides.
• Chemical Biology & Probe Development: Utilized in the synthesis of molecular probes and labeled compounds for diagnostic and research purposes.
• Liquid Crystal & Polymer Chemistry: Acts as a synthetic intermediate for creating advanced polymers and liquid crystal materials with tailored properties.

Basic Information

Product Name	Methyl 2-(2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)phenyl)acetate
CAS No.	956229-86-0
Molecular Formula	C₁₇H₂₅BO₄
Molecular Weight	304.19 g/mol
Synonyms	2-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetic acid methyl ester; Methyl (2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate; [2-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-acetic acid methyl ester; Methyl 2-[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetate; Pinacol ester of (2-(methoxycarbonylmethyl)phenyl)boronic acid
EINECS	Contact for details

Quality Control

Our Methyl 2-(2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)phenyl)acetate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent hydrolysis of the boronic ester functionality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.