Description

n-Phenyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidin-2-Amine is a high-purity, advanced pharmaceutical intermediate featuring a pyrimidine core and a pinacol boronate ester functional group. This compound is a critical building block in modern medicinal chemistry, enabling efficient cross-coupling reactions for the synthesis of complex bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly in oncology and antiviral research.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a key boronic ester reagent for constructing biaryl and heterobiaryl structures in drug discovery pipelines.
• Pharmaceutical Intermediate: A vital precursor in the synthesis of active pharmaceutical ingredients (APIs) targeting kinase inhibition and other specific biological pathways.
• Medicinal Chemistry Research: Used extensively in lead optimization and structure-activity relationship (SAR) studies to develop novel drug candidates.
• Chemical Biology Probes: Employed in the creation of molecular probes for studying enzyme function and cellular signaling processes.
• Agrochemical Development: Potential intermediate for synthesizing novel compounds with herbicidal or pesticidal activity.
• Material Science Research: Can be utilized in the development of organic electronic materials and metal-organic frameworks (MOFs).

Basic Information

Product Name	n-Phenyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidin-2-Amine
CAS No.	956128-05-5
Molecular Formula	C16H20BN3O2
Molecular Weight	297.16 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-phenylpyrimidin-2-amine; 2-Pyrimidinamine, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-phenyl-; N-Phenyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine; 5-(Pinacolatoboryl)-N-phenylpyrimidin-2-amine; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-anilinopyrimidine; CAS 956128-05-5
EINECS	Contact for details

Quality Control

Our n-Phenyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidin-2-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.