Description

2-Bromo-5-Nitro-3-(Trifluoromethyl)Pyridine is a high-value, multi-functional heterocyclic building block essential for advanced chemical synthesis. Its unique structure, featuring bromo, nitro, and trifluoromethyl substituents on a pyridine core, makes it a critical intermediate for introducing specific functionalities into target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infective applications.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Research: Serves as a building block for creating functionalized ligands, organic semiconductors, and advanced polymers with tailored electronic properties.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Buchwald-Hartwig amination, enabling rapid diversification of molecular libraries.
• Fluorine Chemistry: The presence of the CF3 group makes it valuable for studying fluorine's effects on lipophilicity, bioavailability, and binding affinity in drug design.

Basic Information

Product Name	2-Bromo-5-Nitro-3-(Trifluoromethyl)Pyridine
CAS No.	956104-42-0
Molecular Formula	C6H2BrF3N2O2
Molecular Weight	270.99 g/mol
Synonyms	3-(Trifluoromethyl)-2-bromo-5-nitropyridine; 2-Bromo-5-nitro-3-trifluoromethylpyridine; 5-Nitro-2-bromo-3-(trifluoromethyl)pyridine; Pyridine, 2-bromo-5-nitro-3-(trifluoromethyl)-; 956104-42-0
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-5-Nitro-3-(Trifluoromethyl)Pyridine is produced and tested under a strict quality management system. We guarantee high chemical purity and consistency to meet the exacting standards of process chemistry and scale-up. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) with detailed chromatographic data (HPLC/GC) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.