Description

[4-(4-Methoxyphenyl)-8-Methyl-2-Oxochromen-7-Yl] (2S)-3-(1H-Indol-3-Yl)-2-[(2-Methylpropan-2-Yl)Oxycarbonylamino]Propanoate is a high-purity, complex organic intermediate designed for advanced pharmaceutical synthesis and research. This compound is valued for its unique molecular scaffold, which combines coumarin and tryptophan-derived moieties, making it a critical building block for developing novel active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the discovery and process development of new therapeutic agents, particularly in areas requiring sophisticated chiral intermediates.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of novel drug candidates, especially those targeting neurological or oncological pathways.
• Research & Development (R&D): Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization processes.
• Process Chemistry: Employed in scaling up synthetic routes for new chemical entities (NCEs) under Good Manufacturing Practice (GMP) conditions.
• Bioconjugation & Probe Development: Its functional groups make it suitable for creating fluorescent probes or bioconjugates for biochemical assays.
• Academic Research: Utilized in university laboratories for studies in organic synthesis methodology and heterocyclic chemistry.

Basic Information

Product Name	[4-(4-Methoxyphenyl)-8-Methyl-2-Oxochromen-7-Yl] (2S)-3-(1H-Indol-3-Yl)-2-[(2-Methylpropan-2-Yl)Oxycarbonylamino]Propanoate
CAS No.	956044-42-1
Molecular Formula	C34H32N2O7
Molecular Weight	580.63 g/mol
Synonyms	Boc-Tryptophan Coumarin Ester; (2S)-2-[(tert-Butoxycarbonyl)amino]-3-(1H-indol-3-yl)propanoic acid 7-[(4-methoxyphenyl)-8-methyl-2-oxo-2H-chromen-4-yl] ester; 4-(4-Methoxyphenyl)-8-methyl-2-oxo-2H-chromen-7-yl N-Boc-L-tryptophanate; tert-Butyl (S)-(1-(7-((4-methoxyphenyl)-8-methyl-2-oxo-2H-chromen-4-yl)oxy)-1-oxo-3-(1H-indol-3-yl)propan-2-yl)carbamate; Coumarin-Boc-Trp-OMe derivative; CAS 956044-42-1
EINECS	Contact for details

Quality Control

Our [4-(4-Methoxyphenyl)-8-Methyl-2-Oxochromen-7-Yl] (2S)-3-(1H-Indol-3-Yl)-2-[(2-Methylpropan-2-Yl)Oxycarbonylamino]Propanoate is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure high chemical and isomeric purity suitable for demanding R&D and pre-clinical applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in a dry environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% (S-isomer)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.