Description

1-[4-(Trifluoromethyl)-3-Pyridinyl]-Ethanone is a high-value trifluoromethylated pyridine derivative, a key building block in modern synthetic chemistry. Its molecular structure, featuring a ketone group adjacent to a trifluoromethyl-substituted pyridine ring, makes it an essential intermediate for creating complex molecules with enhanced biological activity and physicochemical properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve metabolic stability and lipophilicity.
• Material Science: Serves as a building block for advanced organic materials, including liquid crystals and organic semiconductors, due to its electron-withdrawing characteristics.
• Chemical Synthesis: Employed in cross-coupling reactions, such as Suzuki and Buchwald-Hartwig aminations, to construct complex heterocyclic systems for various R&D purposes.
• Fluorine Chemistry Studies: A valuable reference compound for investigating the influence of the trifluoromethyl group on the reactivity and properties of pyridine-based molecules.

Basic Information

Product Name	1-[4-(Trifluoromethyl)-3-Pyridinyl]-Ethanone
CAS No.	955997-27-0
Molecular Formula	C8H6F3NO
Molecular Weight	189.14 g/mol
Synonyms	4-(Trifluoromethyl)nicotinophenone; 3-Acetyl-4-(trifluoromethyl)pyridine; 1-(4-(Trifluoromethyl)pyridin-3-yl)ethan-1-one; 3-Pyridinyl, 4-(trifluoromethyl)-, ethanone deriv.; Ethanone, 1-[4-(trifluoromethyl)-3-pyridinyl]-; 4-(Trifluoromethyl)-3-acetylpyridine
EINECS	Contact for details

Quality Control

Our 1-[4-(Trifluoromethyl)-3-Pyridinyl]-Ethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment supports compliance with ICH guidelines and cGMP standards for use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents and strong bases. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.