Description

1H-Indole-6-Carboxamide, 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-value, advanced pharmaceutical intermediate featuring a pinacol boronate ester functional group. This compound is critical for modern synthetic chemistry, enabling efficient cross-coupling reactions to construct complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Suzuki-Miyaura Cross-Coupling Reagent: A key building block for creating carbon-carbon bonds in the synthesis of complex indole derivatives.
• Pharmaceutical Intermediate: Used in the research and development of potential drug candidates targeting various therapeutic areas.
• Agrochemical Synthesis: Serves as a precursor in the creation of novel herbicides, fungicides, and insecticides.
• Material Science Research: Employed in the development of organic electronic materials and functional polymers.
• Chemical Biology Probes: Utilized to create labeled compounds for studying biological pathways and mechanisms.
• Process Chemistry & Scale-Up: Supports the transition from laboratory-scale discovery to commercial manufacturing processes.

Basic Information

Item	Details
Product Name	1H-Indole-6-Carboxamide, 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	955978-86-6
Molecular Formula	C15H19BN2O3
Molecular Weight	286.14 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-6-carboxamide; 4-BPin-1H-indole-6-carboxamide; 6-Carbamoyl-1H-indol-4-ylboronic acid pinacol ester; 4-(Pinacolatoboryl)-1H-indole-6-carboxamide; PINACOL 4-CARBAMOYL-1H-INDOL-4-YLBORONATE
EINECS	Contact for details

Quality Control

Every batch of 1H-Indole-6-Carboxamide, 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is produced and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive coupling reactions and pharmaceutical applications. A detailed Certificate of Analysis (COA) including purity (HPLC), identity confirmation (NMR, IR), and impurity profile is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.