Description

1H-Indole, 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-6-(Trifluoromethyl)- is a high-value, multi-functional indole-based boronic ester building block, essential for modern synthetic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone for constructing complex molecular architectures. This compound is critically needed by pharmaceutical, agrochemical, and advanced materials researchers for developing novel active ingredients, functional polymers, and electronic materials.

Application

• Pharmaceutical Intermediate: A key synthon for constructing indole-based drug candidates targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science: Serves as a precursor for organic semiconductors, OLED (Organic Light-Emitting Diode) materials, and conductive polymers due to the indole and trifluoromethyl motifs.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes and activity-based protein profiling (ABPP) reagents leveraging the boronic ester handle.
• Ligand & Catalyst Development: Utilized to create novel bidentate or tridentate ligands for transition metal catalysis.
• Academic & Contract Research: A fundamental building block for methodological development in organic synthesis and medicinal chemistry programs.

Basic Information

Item	Detail
Product Name	1H-Indole, 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-6-(Trifluoromethyl)-
CAS No.	955978-82-2
Molecular Formula	C15H17BF3NO2
Molecular Weight	311.11 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)-1H-indole; 6-(Trifluoromethyl)-1H-indole-4-boronic acid pinacol ester; 4-Borono-6-(trifluoromethyl)-1H-indole, pinacol ester; 6-Trifluoromethyl-1H-indole-4-boronic acid pinacol ester; 4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-6-trifluoromethyl-1H-indole; 1H-Indole-4-boronic acid, 6-(trifluoromethyl)-, pinacol ester
EINECS	Contact for details

Quality Control

Every batch of our 1H-Indole, 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-6-(Trifluoromethyl)- is manufactured and tested under strict quality management systems. We guarantee high chemical purity and lot-to-lot consistency, which is critical for reproducible cross-coupling reactions. Comprehensive Certificates of Analysis (COA) detailing identity, purity (by HPLC/NMR), and impurity profiles are provided with each shipment to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent decomposition and maintain reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.