Description

7'-tert-Butyldimethylsilyloxy-6',7'-Dihydro-6'-Hydroxy-4',6'-Dimethyl-Spiro[Cyclopropane-1,5'-[5H]Inden]-2'(3'H)-One is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and cyclopropane-fused indanone structure. This compound is of significant value for its role as a key synthetic building block in the research and development of novel active pharmaceutical ingredients (APIs). It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of complex organic molecules for therapeutic applications.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of proprietary drug candidates, particularly those targeting central nervous system (CNS) disorders or inflammatory pathways.
• Medicinal Chemistry Research: Used as a scaffold or building block for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Process Chemistry Development: Employed in the optimization and scale-up of synthetic routes for potential APIs, requiring high chemical purity and batch-to-batch consistency.
• Academic & Institutional Research: Utilized in universities and research institutes for methodological studies in organic synthesis, focusing on spirocycle formation and stereoselective transformations.
• Contract Manufacturing (CDMO): Supplied to contract development and manufacturing organizations for the cGMP production of clinical trial materials.

Basic Information

Item	Detail
Product Name	7'-tert-Butyldimethylsilyloxy-6',7'-Dihydro-6'-Hydroxy-4',6'-Dimethyl-Spiro[Cyclopropane-1,5'-[5H]Inden]-2'(3'H)-One
CAS No.	955978-16-2
Molecular Formula	C20H32O3Si
Molecular Weight	348.56 g/mol
Synonyms	7'-O-(tert-Butyldimethylsilyl)-6',7'-dihydro-6'-hydroxy-4',6'-dimethylspiro[cyclopropane-1,5'-inden]-2'(3'H)-one; 6'-Hydroxy-4',6'-dimethyl-7'-(tert-butyldimethylsilyloxy)spiro[cyclopropane-1,5'-indan]-2'(3'H)-one; TBDMS-protected spirocyclopropyl indanone derivative; CAS 955978-16-2
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch is subjected to comprehensive analytical characterization, including HPLC for purity and identity confirmation via NMR and MS. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring full traceability and compliance with client specifications for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.