Description

tert-Butyl 4-(2-Aminophenyl)-5,6-dihydropyridine-1(2H)-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a unique bicyclic structure with both amino and tert-butoxycarbonyl (Boc) protecting groups. This compound is critical for the synthesis of complex molecules, offering a versatile scaffold for medicinal chemistry research and development. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers for the production of novel active pharmaceutical ingredients (APIs) and bioactive compounds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly in central nervous system (CNS) and oncology research.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization due to its functionalized dihydropyridine and aniline moieties.
• API Synthesis: Used in the multi-step synthesis of potential Active Pharmaceutical Ingredients (APIs), where the Boc group provides orthogonal protection for the amine functionality.
• Chemical Biology Probes: Employed in the development of chemical probes for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and contract research organizations (CROs) specializing in heterocyclic chemistry.

Basic Information

Product Name	tert-Butyl 4-(2-Aminophenyl)-5,6-dihydropyridine-1(2H)-carboxylate
CAS No.	955397-70-3
Molecular Formula	C16H22N2O2
Molecular Weight	274.36 g/mol
Synonyms	1-Boc-4-(2-aminophenyl)-1,2,3,6-tetrahydropyridine; 4-(2-Aminophenyl)-1,2,3,6-tetrahydropyridine-1-carboxylic acid tert-butyl ester; tert-Butyl 4-(2-aminophenyl)-1,2,3,6-tetrahydropyridine-1-carboxylate; 1-(tert-Butoxycarbonyl)-4-(2-aminophenyl)-1,2,3,6-tetrahydropyridine; 4-(2-Aminophenyl)-1-Boc-1,2,3,6-tetrahydropyridine; 1-N-Boc-4-(2-aminophenyl)-1,2,3,6-tetrahydropyridine; Boc-4-(2-aminophenyl)-1,2,3,6-tetrahydropyridine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(2-Aminophenyl)-5,6-dihydropyridine-1(2H)-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles suitable for pharmaceutical R&D applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to prevent degradation. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.