Description

Solanezumab CAS NO 955085-14-0 is a humanized monoclonal antibody designed to target soluble amyloid-beta peptides. This product is of significant interest in the research and development of novel therapeutic strategies for neurodegenerative conditions. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on neuroscience and immunology.

Application

• Biopharmaceutical Research: Key reagent in the study of amyloid-beta pathology and Alzheimer's disease mechanisms.
• Therapeutic Development: Used in preclinical studies for the formulation and efficacy testing of potential neuroprotective treatments.
• Immunoassay Development: Serves as a critical component in the development of diagnostic assays for detecting specific amyloid-beta isoforms.
• Cell Culture & In Vitro Studies: Applied in cellular models to investigate antibody-mediated clearance of soluble protein aggregates.
• Reference Standard: Acts as a high-purity biological reference material for quality control and method validation in related bioanalytical workflows.

Basic Information

Product Name	Solanezumab
CAS No.	955085-14-0
Molecular Formula	C6470H10012N1736O2010S44
Molecular Weight	Approx. 146 kDa
Synonyms	LY2062430; Anti-Amyloid Beta, Soluble, Monoclonal Antibody; h4G8; Solanezumab (USAN/INN); IgG1, anti-(human amyloid beta peptide) (human γ1-chain), disulfide with human λ-chain, dimer
EINECS	Contact for details

Quality Control

Our Solanezumab is manufactured under stringent conditions to ensure the highest standards of purity and biological activity. Each batch undergoes comprehensive analytical testing, including SDS-PAGE, SEC-HPLC for purity and aggregation analysis, peptide mapping, and endotoxin testing. Certificates of Analysis (COA) detailing identity, purity, potency, and safety profiles are available upon request to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C to -80°C. Avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive) and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear solution
Identification (Mass Spec)	Conforms
Purity (SEC-HPLC)	≥ 95.0% (Monomer)
Protein Content (A280)	As per COA
Endotoxin	< 1.0 EU/mg
Biological Activity (Binding ELISA)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.