Description

Muromonab-Cd3 is a monoclonal antibody specifically targeting the CD3 antigen on T lymphocytes, playing a critical role in immunosuppressive therapy. Its primary value lies in its ability to modulate the immune system, making it an essential agent in managing organ transplant rejection. This product is vital for pharmaceutical manufacturers and research institutions engaged in developing and producing advanced immunotherapies and biologics. The compound Muromonab-Cd3 CAS NO 140608-64-6 represents a high-purity biological agent for specialized therapeutic applications.

Application

• Immunosuppressive Therapy: Primary use for the prevention and treatment of acute organ transplant rejection, particularly in kidney, heart, and liver transplants.
• Pharmaceutical Active Ingredient: Serves as the key biological component in the formulation of finished injectable drug products.
• Clinical Research: Used in investigational studies for autoimmune diseases and other conditions involving T-cell mediated pathologies.
• Reference Standard: Acts as a high-purity standard for quality control and assay development in biopharmaceutical laboratories.
• Biologics Development: A critical reagent in the R&D of novel monoclonal antibody-based therapies and biosimilars.

Basic Information

Product Name	Muromonab-Cd3
CAS No.	140608-64-6
Molecular Formula	C6420H9878N1692O2011S44
Molecular Weight	Approx. 144 kDa
Synonyms	Muromonab-CD3; OKT3; Orthoclone OKT3; Anti-CD3 Monoclonal Antibody; Monoclonal Antibody to CD3; CD3 Antibody; Anti-Human CD3; Immunosuppressive Monoclonal Antibody; T-Cell Receptor Complex Antibody
EINECS	Contact for details

Quality Control

Our Muromonab-Cd3 is manufactured under strict quality systems to ensure it meets the rigorous standards required for pharmaceutical and research use. Each batch is subjected to comprehensive analytical testing, including purity assessment, potency testing, and characterization of biological activity. A detailed Certificate of Analysis (COA) documenting identity, purity, sterility (where applicable), endotoxin levels, and other critical parameters is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term stability, store lyophilized material at 2-8°C. Reconstituted solutions should be used immediately or stored as directed by specific protocol, typically at 2-8°C for short periods. Avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (SDS-PAGE / SEC-HPLC)	≥ 95%
Protein Content (UV Absorption)	≥ 90% of label claim
Potency (Cell-based Assay)	Conforms to reference activity
Endotoxin (LAL)	< 10 EU/mg
Sterility (Membrane Filtration)	Sterile (for sterile-grade material)
Moisture Content (KF)	< 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.