Description

Tocilizumab CAS NO 375823-41-9 is a recombinant humanized monoclonal antibody that specifically targets the interleukin-6 (IL-6) receptor. This product is critical for research and development in the biopharmaceutical sector, offering a high-purity standard for investigative and therapeutic applications. It is primarily utilized by pharmaceutical companies, biotechnology research institutions, and clinical diagnostic developers focused on immunology and inflammatory diseases.

Application

• Active Pharmaceutical Ingredient (API) for the formulation of biologic drugs targeting IL-6 mediated pathways.
• Biomedical Research as a critical tool for studying cytokine signaling, autoimmune disorders, and inflammatory responses in vitro and in vivo.
• Reference Standard for quality control and assay development in biopharmaceutical manufacturing and analytical laboratories.
• Pre-clinical and Clinical Development for investigative new drug (IND) applications and therapeutic efficacy studies.
• Diagnostic Reagent Development for creating assays that measure IL-6 pathway activity or for companion diagnostics.

Basic Information

Product Name	Tocilizumab
CAS No.	375823-41-9
Molecular Formula	C6428H9976N1720O2018S46
Molecular Weight	Approx. 145 kDa
Synonyms	Atlizumab; Anti-IL-6R monoclonal antibody; rhuMAb IL-6R; ACTEMRA® (Trade Name); Interleukin-6 Receptor Inhibitor; IL-6R mAb; MRA; RoActemra
EINECS	Contact for details

Quality Control

Our Tocilizumab is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing including purity analysis by SEC-HPLC, potency assays, and identity confirmation to ensure it meets rigorous standards for research and development use. Certificates of Analysis (COA) detailing specifications and test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive) and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear to slightly opalescent solution
Identification (SEC-HPLC / MS)	Conforms to reference standard
Purity (SEC-HPLC)	≥ 98.0% (Monomer)
Protein Content (UV/A280)	95.0 - 105.0 % of label claim
Biological Activity (Cell-based assay)	Within defined range of reference
Endotoxin	< 1.0 EU/mg
Host Cell Proteins (HCP)	< 100 ppm
Residual DNA	< 10 pg/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.