Description

Monalizumab CAS NO 1228763-95-8 is a high-purity, investigational monoclonal antibody designed for targeted immunotherapy. This compound is of significant interest for its role in modulating the immune system by targeting specific checkpoint receptors. It is primarily developed for use by pharmaceutical companies, biotechnology research firms, and clinical research organizations engaged in advanced oncology and immunology programs. Its development underscores a commitment to creating next-generation therapeutic agents for complex diseases.

Application

• Oncology Research: Investigated as a potential therapeutic agent in various cancer immunotherapy regimens, particularly for solid tumors.
• Immunology Studies: Used in preclinical and clinical research to understand and modulate immune checkpoint pathways.
• Biopharmaceutical Development: Serves as a key intermediate or reference standard in the development and quality control of biologic drugs.
• Clinical Trial Materials: Supplied as a critical component for Phase I, II, and III clinical trials evaluating novel combination therapies.
• Drug Discovery Platforms: Utilized in high-throughput screening and validation assays to identify synergistic drug candidates.

Basic Information

Product Name	Monalizumab
CAS No.	1228763-95-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	IPH2201; Anti-KLRG1 / KLRG-1 Antibody; Monoclonal Antibody IPH2201; KLRG1 Blocking Antibody; Monalizumab (USAN/INN)
EINECS	Contact for details

Quality Control

Our Monalizumab is manufactured under strict quality systems to ensure the highest standards of purity and biological activity. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing critical quality attributes such as purity, potency, and identity. We adhere to relevant Good Manufacturing Practice (GMP) guidelines for investigational products, ensuring traceability and consistency for research and clinical use.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Avoid repeated freeze-thaw cycles. The product should be handled under aseptic conditions appropriate for biologic materials to maintain sterility and activity.

Specification

Item	Specification
Appearance	Clear to slightly opalescent, colorless to pale yellow solution
Identification (HPLC/MS)	Conforms to reference standard
Purity (SEC-HPLC)	≥ 95.0% (Monomer)
Protein Concentration	As per COA (typically 1-10 mg/mL)
Endotoxin	< 1.0 EU/mg
Sterility	Sterile (where applicable)
Biological Activity (Binding ELISA/Cell-based Assay)	As per COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.