Description

trans-3-Fluoropiperidin-4-Ol (Wx601313) is a fluorinated piperidine derivative, a versatile chiral building block of significant interest in modern synthetic chemistry. Its core value lies in the strategic incorporation of fluorine and hydroxyl groups, which are critical for modulating the physicochemical and biological properties of target molecules. This high-purity intermediate is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active pharmaceutical ingredients (APIs) and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of central nervous system (CNS) drugs, enzyme inhibitors, and receptor modulators.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atom enhances bioavailability and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetics and Bioisosteres: The fluorinated piperidine scaffold is valuable for creating peptide mimics and bioisosteric replacements in drug design.
• Material Science Research: Investigated as a building block for specialty polymers and advanced organic materials.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	trans-3-Fluoropiperidin-4-Ol (Wx601313)
CAS No.	955082-95-8
Molecular Formula	C5H10FNO
Molecular Weight	119.14 g/mol
Synonyms	trans-4-Hydroxy-3-fluoropiperidine; (3R,4R)-3-Fluoropiperidin-4-ol; (3S,4S)-3-Fluoropiperidin-4-ol; 3-Fluoro-4-hydroxypiperidine; 4-Piperidinol, 3-fluoro-, (3R,4R)-rel-; WX-601313; Wx601313; FC-1137
EINECS	Contact for details

Quality Control

Our trans-3-Fluoropiperidin-4-Ol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding R&D and scale-up applications. We provide comprehensive analytical data, including chiral purity verification by HPLC. A detailed Certificate of Analysis (COA) is supplied with each batch, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.