Description

6-Cyclopropyl-1-isobutyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid is a high-purity, advanced pharmaceutical intermediate belonging to the pyrazolopyridine class of heterocyclic compounds. This compound is of significant commercial interest for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is primarily sought after by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the research and development of new drug candidates.
• Kinase Inhibitor Synthesis: Used in the construction of core structures for potential kinase inhibitor therapies targeting various diseases.
• Medicinal Chemistry Research: Provides a versatile heterocyclic scaffold for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry & Scale-Up: Employed in route scouting and the development of robust, scalable synthetic processes for API manufacturing.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method development.
• Custom Synthesis Building Block: Utilized by fine chemical suppliers for the preparation of more complex, customer-specific molecules.

Basic Information

Product Name	6-Cyclopropyl-1-isobutyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic Acid
CAS No.	954275-78-6
Molecular Formula	C15H17N3O2
Molecular Weight	271.32 g/mol
Synonyms	6-Cyclopropyl-1-(2-methylpropyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid; 1H-Pyrazolo[3,4-b]pyridine-4-carboxylic acid, 6-cyclopropyl-1-(2-methylpropyl)-; 954275-78-6; 6-Cyclopropyl-1-isobutyl-1H-pyrazolo[3,4-b]pyridin-4-carboxylic acid; 6-Cyclopropyl-1-isobutyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylate (acid form)
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is characterized using advanced analytical techniques to confirm identity, purity, and consistency. Certificates of Analysis (COA) detailing specific results for each parameter are available upon request. We adhere to a quality management system designed to meet the stringent requirements of pharmaceutical and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound is stable under these conditions but should be kept away from strong acids and organic solvents. For long-term storage, consider inert atmosphere conditions to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.