Description

2-(Bromomethyl)-5-Fluoropyridine is a versatile and high-purity halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its dual functional groups, which enable efficient cross-coupling reactions and nucleophilic substitutions, facilitating the rapid construction of complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries, where it is used to develop novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Building block for creating novel herbicides, fungicides, and insecticides that leverage the fluoropyridine moiety for enhanced bioactivity and environmental stability.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for transition metal catalysis, enabling more efficient and selective synthetic processes.
• Material Science Research: Serves as a monomer or functionalization agent in the development of advanced polymers, liquid crystals, and electronic materials.
• Cross-Coupling Reactions: The bromomethyl group is an excellent electrophile for Suzuki, Stille, and Negishi cross-coupling reactions to form new carbon-carbon bonds.
• Nucleophilic Substitution: Reacts with a wide range of nucleophiles (amines, thiols, alkoxides) to introduce diverse functional groups onto the pyridine core.

Basic Information

Product Name	2-(Bromomethyl)-5-Fluoropyridine
CAS No.	954225-35-5
Molecular Formula	C6H5BrFN
Molecular Weight	190.01 g/mol
Synonyms	5-Fluoro-2-(bromomethyl)pyridine; 2-Bromomethyl-5-fluoropyridine; (5-Fluoropyridin-2-yl)methyl bromide; 5-Fluoro-2-pyridinemethyl bromide; 954225-35-5; 5-Fluoro-2-(bromomethyl)pyridine; 2-Pyridinemethyl bromide, 5-fluoro-
EINECS	Contact for details

Quality Control

Every batch of 2-(Bromomethyl)-5-Fluoropyridine is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and purity. Our standard grade meets a typical purity specification of ≥97% (by HPLC), with stringent controls on related substances and residual solvents. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and safety parameters is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.