Description

1-tert-Butyl 4-Ethyl 4-(Pyridin-4-Yl)Piperidine-1,4-Dicarboxylate is a high-purity, advanced pharmaceutical intermediate featuring a piperidine core substituted with pyridine and carboxylate protecting groups. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for creating targeted drug candidates, particularly in neurological and oncological therapeutic areas.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies for new drug discovery.
• Process Chemistry Development: Serves as a critical starting material for scaling up synthetic routes under GMP conditions.
• Neurological Drug Candidates: Employed in the research of compounds targeting central nervous system (CNS) disorders.
• Oncology Research: Utilized as a precursor in the development of potential kinase inhibitors and other anticancer agents.
• Chemical Biology Probes: Acts as a scaffold for developing tool compounds to study biological pathways and protein function.
• Custom Synthesis: A foundational substrate for contract research and manufacturing organizations (CROs/CMOs) offering bespoke chemical synthesis.

Basic Information

Product Name	1-tert-Butyl 4-Ethyl 4-(Pyridin-4-Yl)Piperidine-1,4-Dicarboxylate
CAS No.	954125-18-9
Molecular Formula	C18H26N2O4
Molecular Weight	334.41 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-4-(ethoxycarbonyl)-4-(pyridin-4-yl)piperidine; 4-Pyridin-4-yl-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester; 1-Boc-4-(ethoxycarbonyl)-4-(4-pyridyl)piperidine; tert-Butyl 4-ethoxycarbonyl-4-(4-pyridyl)piperidine-1-carboxylate; 4-(4-Pyridinyl)-1-piperidinecarboxylic acid 1-(1,1-dimethylethyl) 4-ethyl ester; CAS 954125-18-9; 1-N-Boc-4-(ethoxycarbonyl)-4-(4-pyridyl)piperidine
EINECS	Contact for details

Quality Control

Our 1-tert-Butyl 4-Ethyl 4-(Pyridin-4-Yl)Piperidine-1,4-Dicarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP guidelines for pharmaceutical intermediates and aligns with ICH stability protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. Store away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity (HPLC)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.