Description

(R)-1-(5-(2,2,2-Trifluoroethoxy)Pyridin-2-Yl)Ethanamine Dihydrochloride is a high-purity chiral amine salt, serving as a critical advanced pharmaceutical intermediate. Its value lies in its role as a key building block for the synthesis of complex, biologically active molecules, particularly in the development of new therapeutic agents. This compound is essential for research and development teams in the pharmaceutical and biotechnology sectors, especially those focused on creating novel small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disorder targets.
• Preclinical & Clinical Research: Used in medicinal chemistry for lead optimization and the synthesis of candidate drug compounds for biological screening and pharmacokinetic studies.
• Asymmetric Synthesis: Employed as a chiral auxiliary or precursor in stereoselective synthesis to introduce the (R)-configured ethanamine moiety into complex molecular architectures.
• Chemical Reference Standard: Serves as a high-purity analytical standard for method development, validation, and quality control in pharmaceutical analysis.
• Process Chemistry Development: Used for scaling up synthetic routes and optimizing manufacturing processes for target molecules in pilot plants.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) conducting research in organic synthesis and drug discovery.

Basic Information

Product Name	(R)-1-(5-(2,2,2-Trifluoroethoxy)Pyridin-2-Yl)Ethanamine Dihydrochloride
CAS No.	953780-72-8
Molecular Formula	C9H12Cl2F3N2O
Molecular Weight	301.11 g/mol
Synonyms	(R)-1-[5-(2,2,2-Trifluoroethoxy)-2-pyridinyl]ethanamine dihydrochloride; (R)-1-(5-(2,2,2-Trifluoroethoxy)pyridin-2-yl)ethan-1-amine dihydrochloride; (R)-1-(5-(Trifluoroethoxyl)pyridin-2-yl)ethylamine dihydrochloride; (R)-α-Methyl-5-(2,2,2-trifluoroethoxy)-2-pyridineethanamine dihydrochloride; (R)-TFMPEA dihydrochloride; CAS 953780-72-8
EINECS	Contact for details

Quality Control

Our (R)-1-(5-(2,2,2-Trifluoroethoxy)Pyridin-2-Yl)Ethanamine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.