Description

Lebrikizumab is a high-affinity, humanized monoclonal antibody designed to selectively inhibit interleukin-13 (IL-13), a key cytokine implicated in type 2 inflammation. This targeted mechanism of action makes it a critical active pharmaceutical ingredient (API) for the development of advanced biologic therapeutics. It is primarily utilized by pharmaceutical manufacturers and biotech companies engaged in the research, development, and production of treatments for inflammatory diseases such as atopic dermatitis and asthma.

Application

• Active Pharmaceutical Ingredient (API) for biologic drug formulations targeting IL-13.
• Core component in clinical and commercial-stage therapeutics for moderate-to-severe atopic dermatitis.
• Key material for pre-clinical and clinical research into Th2-mediated inflammatory pathways.
• Essential reference standard for bioanalytical method development and quality control testing.
• Critical raw material for process development and scale-up in biopharmaceutical manufacturing.
• Used in stability studies and comparability assessments for biosimilar development programs.

Basic Information

Product Name	Lebrikizumab
CAS No.	953400-68-5
Molecular Formula	C6440H9916N1704O2016S46
Molecular Weight	Approx. 145 kDa
Synonyms	LY365015; Anti-IL-13 Monoclonal Antibody; IL-13 Inhibitor; MILR1444A; TNX-650; Drug Substance Lebrikizumab; Recombinant Humanized Anti-Interleukin-13 IgG4 Monoclonal Antibody
EINECS	Contact for details

Quality Control

Our Lebrikizumab is manufactured under strict quality management systems. Each batch is subjected to a comprehensive suite of analytical tests including identity confirmation, purity assessment, potency, and impurity profiling to ensure it meets stringent specifications for pharmaceutical use. Certificates of Analysis (COA) documenting compliance with relevant standards are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. For long-term storage, maintain at -70°C. This product is hygroscopic (moisture-sensitive) and should be handled under controlled conditions to prevent degradation. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear to slightly opalescent solution
Identification (HPLC/MS)	Conforms to reference standard
Purity (SEC-HPLC)	≥ 98.0% (Monomer)
Potency (Cell-based assay)	90% - 110% of reference
Protein Content (A280)	As per COA
Endotoxin (LAL)	< 1.0 EU/mg
Host Cell Protein (HCP)	< 100 ppm
Host Cell DNA	< 10 pg/mg
Sterility (Membrane Filtration)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.