Description

2,4-Dichloro-1-[Isocyano-(Toluene-4-Sulfonyl)-Methyl]-Benzene CAS NO 952727-77-4 is a specialized organic synthetic intermediate featuring a reactive isocyano group and a tosyl-protected methylene bridge. This compound matters as a versatile building block for constructing complex molecular architectures, particularly in the development of pharmaceuticals and advanced agrochemicals. It is primarily needed by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and agrochemical industries for synthesizing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Building block for creating advanced herbicides and fungicides with enhanced efficacy and selectivity.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for transition metal catalysis and organocatalysts.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers and functional organic materials.
• Chemical Biology Probes: Utilized in the design and synthesis of activity-based probes for studying enzyme function and biological pathways.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific projects requiring this unique molecular scaffold.

Basic Information

Item	Details
Product Name	2,4-Dichloro-1-[Isocyano-(Toluene-4-Sulfonyl)-Methyl]-Benzene
CAS No.	952727-77-4
Molecular Formula	C15H11Cl2NO2S
Molecular Weight	340.22 g/mol
Synonyms	2,4-Dichloro-α-isocyano-p-tolylsulfonyltoluene; α-Isocyano-2,4-dichlorobenzyl p-Tolyl Sulfone; p-Toluenesulfonyl(2,4-dichlorophenyl)methyl isocyanide; (2,4-Dichlorophenyl)(isocyano)(4-methylphenylsulfonyl)methane; TsCH(CN)Ar (where Ar = 2,4-dichlorophenyl); 952727-77-4; Tosylmethyl isocyanide (TosMIC) derivative
EINECS	Contact for details

Quality Control

Every batch of 2,4-Dichloro-1-[Isocyano-(Toluene-4-Sulfonyl)-Methyl]-Benzene undergoes rigorous analytical testing to ensure high purity, identity, and consistency, meeting the stringent requirements of advanced synthetic applications. Our quality management system is designed to provide full traceability. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to light and propensity for oxidation, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.