Description

4-Nitrophenyl Isocyanate is a versatile and highly reactive aromatic isocyanate derivative, primarily used as a key building block in organic synthesis. Its value lies in its ability to readily form stable ureas and carbamates, making it an essential reagent for introducing the 4-nitrophenyl moiety into more complex molecular architectures. This compound is particularly needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for applications ranging from drug discovery to polymer modification.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing urea or carbamate functional groups.
• Agrochemical Synthesis: Used in the development of herbicides, fungicides, and insecticides where the 4-nitrophenyl group confers specific biological activity.
• Polymer Science: Acts as a cross-linking agent or monomer in the production of specialty polyurethanes and other polymers with enhanced properties.
• Bioconjugation & Labeling Reagent: Employed to modify peptides, proteins, and other biomolecules for analytical or diagnostic purposes.
• Chemical Research: A fundamental reagent in academic and industrial R&D for exploring new organic reactions and synthesizing novel heterocyclic compounds.
• Dye and Pigment Manufacturing: Utilized in the synthesis of certain azo dyes and colorants.

Basic Information

Product Name	4-Nitrophenyl Isocyanate
CAS No.	100-28-7
Molecular Formula	C7H4N2O3
Molecular Weight	164.12 g/mol
Synonyms	p-Nitrophenyl isocyanate; 1-Isocyanato-4-nitrobenzene; 4-Nitrobenzenisocyanate; 4-Nitrophenylcarbonimide; Isocyanic acid 4-nitrophenyl ester; NSC 406071; p-Nitrophenylcarbonylimide; 4-Nitro-phenylisocyanate
EINECS	202-836-5

Quality Control

Our 4-Nitrophenyl Isocyanate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques, including HPLC, GC, and NMR, to verify identity and quantify impurities. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and specific impurity limits is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its moisture-sensitive (hygroscopic) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and degradation. Keep away from heat, sparks, open flames, and incompatible materials such as alcohols, amines, and strong bases.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	54 - 58 °C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.