Description

3,4-Dichlorobenzyl Isocyanide is a versatile and highly reactive organic building block, specifically an isocyanide derivative. Its core value proposition lies in its role as a critical reagent in multicomponent reactions, enabling the efficient synthesis of complex heterocyclic and pharmaceutical intermediates. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity, specialized synthons for innovative synthesis.

Application

• Pharmaceutical Intermediate Synthesis: A key reactant in Passerini and Ugi multicomponent reactions for creating diverse compound libraries and complex drug-like molecules.
• Agrochemical Research & Development: Used in the synthesis of novel herbicides, fungicides, and insecticides, leveraging its ability to introduce the isocyanide functional group into target structures.
• Ligand and Catalyst Preparation: Serves as a precursor for the development of specialized isocyanide-based ligands used in transition metal catalysis.
• Heterocyclic Chemistry: Integral to the construction of various nitrogen-containing heterocycles, which are prevalent in many active pharmaceutical ingredients (APIs).
• Material Science Research: Employed in the synthesis of functionalized polymers and advanced organic materials with tailored properties.
• Chemical Biology Probes: Utilized in the design and synthesis of activity-based probes for studying enzymatic function and protein interactions.

Basic Information

Product Name	3,4-Dichlorobenzyl Isocyanide
CAS No.	1197-36-0
Molecular Formula	C8H5Cl2N
Molecular Weight	186.04 g/mol
Synonyms	1-Isocyano-3,4-dichlorobenzene; (3,4-Dichlorophenyl)methyl isocyanide; 3,4-Dichlorobenzylisocyanide; 3,4-Dichlorobenzyl Isonitrile; α-Isocyano-3,4-dichlorotoluene; NSC 404087; 3,4-Dichlorobenzyl Isocyanide-d0 (for labeled forms)
EINECS	Contact for details

Quality Control

Our 3,4-Dichlorobenzyl Isocyanide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is analyzed using advanced techniques including HPLC, GC, and NMR to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.