Description

2-Chloro-4-Fluoro-1-[Isocyano-(Toluene-4-Sulfonyl)-Methyl]-Benzene is a high-value, multi-functional chemical building block featuring a reactive isocyano group and a tosyl-protected methylene unit. This compound matters for its role as a versatile synthon in advanced organic synthesis, enabling the construction of complex heterocyclic and pharmaceutical scaffolds. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Used in the development of new-generation herbicides and fungicides, leveraging its halogenated aromatic structure for bioactivity.
• Ligand and Catalyst Development: Serves as a building block for creating specialized ligands used in asymmetric catalysis and transition metal complexes.
• Heterocyclic Chemistry: Employed in the construction of complex nitrogen-containing heterocycles like indoles, quinolines, and oxazoles via cycloaddition and multi-component reactions.
• Material Science Research: Investigated as a monomer or cross-linking agent for the development of specialty polymers with unique thermal or optical properties.
• Chemical Biology Probes: Utilized in the design of activity-based probes and molecular tags for studying enzyme function and protein interactions.

Basic Information

Product Name	2-Chloro-4-Fluoro-1-[Isocyano-(Toluene-4-Sulfonyl)-Methyl]-Benzene
CAS No.	952727-75-2
Molecular Formula	C15H11ClFNO2S
Molecular Weight	323.77 g/mol
Synonyms	2-Chloro-4-fluoro-1-[(isocyanotoluenesulfonyl)methyl]benzene; 2-Chloro-4-fluoro-1-[(isocyano)(p-tolylsulfonyl)methyl]benzene; 1-[(Isocyanotoluenesulfonyl)methyl]-2-chloro-4-fluorobenzene; p-Tolylsulfonyl(2-chloro-4-fluorophenyl)methyl isocyanide; TosMIC Derivative (2-Chloro-4-fluoro); (2-Chloro-4-fluorophenyl)(isocyano)(4-methylphenylsulfonyl)methane; Benzene, 2-chloro-4-fluoro-1-[isocyano(4-methylphenylsulfonyl)methyl]-
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-Fluoro-1-[Isocyano-(Toluene-4-Sulfonyl)-Methyl]-Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from strong acids, strong bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.