Description

5-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-7,8-Dihydronaphthalene-2-Carbonitrile is a high-purity, advanced pharmaceutical intermediate and key building block in modern synthetic chemistry. This compound is valued for its role as a versatile boronic ester pinacol ester, enabling critical carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the synthesis of complex, functionalized organic molecules.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables efficient palladium-catalyzed coupling with aryl or vinyl halides to construct biaryl and conjugated systems essential for advanced materials and ligands.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific naphthalene-based architectures.
• Organic Light-Emitting Diode (OLED) Materials: Serves as a precursor for electron-transport materials and host molecules in display and lighting technologies.
• Ligand and Catalyst Development: Employed in the creation of novel chiral ligands and organometallic catalysts for asymmetric synthesis.
• Polymer and Material Science: A monomer or functionalization agent for creating specialty polymers with tailored electronic or optical properties.
• Chemical Biology Probes: Used to synthesize labeled compounds and molecular probes for biochemical and diagnostic research.

Basic Information

Item	Details
Product Name	5-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-7,8-Dihydronaphthalene-2-Carbonitrile
CAS No.	952675-93-3
Molecular Formula	C₁₇H₂₀BNO₂
Molecular Weight	281.16 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-7,8-dihydronaphthalene-2-carbonitrile; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6,7,8-tetrahydronaphthalene-2-carbonitrile; 2-Cyano-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-7,8-dihydronaphthalene; 5,6,7,8-Tetrahydro-2-naphthonitrile-5-boronic acid pinacol ester; 5-(Pinacolboryl)-7,8-dihydronaphthalene-2-carbonitrile; 5-(4,4,5,5-Tetramethyl-2-dioxa-3-boracyclopent-2-yl)-7,8-dihydronaphthalene-2-carbonitrile; 952675-93-3
EINECS	Contact for details

Quality Control

Every batch of 5-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-7,8-Dihydronaphthalene-2-Carbonitrile is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and high purity. Our standard quality commitment includes comprehensive analysis via HPLC, NMR, and MS to confirm identity and purity, meeting the stringent requirements for pharmaceutical R&D and process chemistry. A detailed Certificate of Analysis (COA) is provided with each shipment, and custom specifications can be developed to support your specific project needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged use to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.