Description

6-Cyanopyridine-2-Boronic Acid Pinacol Ester is a high-value boronic ester building block essential for modern synthetic chemistry, particularly in cross-coupling reactions. Its bifunctional structure, featuring both a cyano group and a protected boronic acid, makes it a versatile intermediate for constructing complex heterocyclic systems. This compound is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of active ingredients and advanced materials.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for the palladium-catalyzed formation of carbon-carbon bonds, enabling the synthesis of biaryl and heterobiaryl structures prevalent in drug discovery.
• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of active pharmaceutical ingredients (APIs), especially those containing functionalized pyridine cores.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific pyridine-based architectures.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Material Science Research: A precursor for creating organic electronic materials, such as those used in OLEDs and semiconductors, due to its conjugated system.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and inhibitors for biochemical and pharmacological studies.

Basic Information

Product Name	6-Cyanopyridine-2-Boronic Acid Pinacol Ester
CAS No.	952402-79-8
Molecular Formula	C₁₃H₁₅BN₂O₂
Molecular Weight	242.08 g/mol
Synonyms	2-Cyano-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 6-Cyano-2-pyridineboronic acid pinacol ester; (6-Cyanopyridin-2-yl)boronic acid pinacol ester; 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-6-cyanopyridine; Pinacol 6-Cyanopyridine-2-boronate; 6-CN-Py-2-Bpin; B-(6-Cyanopyridin-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 6-Cyanopyridine-2-Boronic Acid Pinacol Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and scale-up applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and LC-MS, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications. We support cGMP and ISO standards for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and must be handled under dry conditions to prevent hydrolysis of the boronic ester moiety. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.