Description

6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine-2-Carbonitrile is a high-value, multi-functional boronic ester derivative that serves as a critical synthetic intermediate. Its core value proposition lies in enabling precise carbon-carbon bond formation, a fundamental step in constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is primarily utilized in Suzuki-Miyaura cross-coupling reactions to introduce the pyridine-carbonitrile pharmacophore into target molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and other small-molecule drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require the pyridine-carbonitrile moiety for biological activity.
• Material Science Research: Serves as a precursor for creating novel organic ligands, metal-organic frameworks (MOFs), and functional polymers with tailored electronic or optical properties.
• Chemical Biology Probes: Employed in the development of molecular probes and diagnostic agents due to its ability to be selectively incorporated into larger structures via cross-coupling.
• Academic & Contract Research: A vital reagent for synthetic organic chemistry research in academic institutions and contract research organizations (CROs) exploring new catalytic methodologies.

Basic Information

Product Name	6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine-2-Carbonitrile
CAS No.	952402-29-8
Molecular Formula	C13H17BN2O2
Molecular Weight	244.10 g/mol
Synonyms	2-Cyano-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)picolinonitrile; 2-Pyridinecarbonitrile, 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; Pinacol 2-Cyano-6-pyridylboronate; 6-(Pinacolatoboryl)picolinonitrile; 6-Borono-2-cyanopyridine pinacol ester; 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-cyanopyridine
EINECS	Contact for details

Quality Control

Our 6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine-2-Carbonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and our quality protocols are designed to meet the stringent requirements of pharmaceutical R&D and production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.