Description

Methyl 5-(Trifluoromethyl)-1-Tosyl-1H-Pyrrolo[3,2-B]Pyridine-2-Carboxylate is a high-value, multi-functional heterocyclic building block designed for advanced organic synthesis. This compound is critical for medicinal chemistry research and development, offering a versatile scaffold for creating novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers specializing in the synthesis of complex, fluorinated molecules for therapeutic applications.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization due to its fused pyrrolopyridine core and trifluoromethyl group.
• Fluorinated Compound Synthesis: The trifluoromethyl group provides metabolic stability and lipophilicity, making this compound essential for developing modern fluorinated pharmaceuticals.
• Agrochemical Development: Used in research for creating new active ingredients with enhanced efficacy and environmental profiles.
• Material Science Research: Potential building block for organic electronic materials and advanced polymers due to its complex aromatic structure.

Basic Information

Product Name	Methyl 5-(Trifluoromethyl)-1-Tosyl-1H-Pyrrolo[3,2-B]Pyridine-2-Carboxylate
CAS No.	952182-33-1
Molecular Formula	C18H13F3N2O4S
Molecular Weight	410.37 g/mol
Synonyms	Methyl 5-(trifluoromethyl)-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[3,2-b]pyridine-2-carboxylate; 1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid, 5-(trifluoromethyl)-1-[(4-methylphenyl)sulfonyl]-, methyl ester; 952182-33-1; 1-Tosyl-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-2-carboxylic acid methyl ester; Methyl 1-tosyl-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-2-carboxylate
EINECS	Contact for details

Quality Control

Our Methyl 5-(Trifluoromethyl)-1-Tosyl-1H-Pyrrolo[3,2-B]Pyridine-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client requirements for research or GMP-grade material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contaminants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.