Description

Methyl 1-Tosyl-1H-Pyrrolo[3,2-B]Pyridine-2-Carboxylate CAS NO 952182-32-0 is a high-purity, synthetically valuable heterocyclic building block used in advanced pharmaceutical research and development. This compound serves as a critical intermediate for the synthesis of complex molecules, particularly in the creation of novel kinase inhibitors and other biologically active agents. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of targeted therapeutics, especially kinase inhibitors for oncology and inflammatory diseases.
• Medicinal Chemistry Research: Used in hit-to-lead optimization and structure-activity relationship (SAR) studies due to its versatile pyrrolopyridine scaffold.
• Process Chemistry & Scale-Up: Serves as a defined intermediate for the development and optimization of scalable synthetic routes to Active Pharmaceutical Ingredients (APIs).
• Bioconjugation & Probe Development: The tosyl and ester functional groups allow for further chemical modifications, making it useful for creating biochemical probes and labeled compounds.
• Academic & Contract Research: Employed in university and CRO settings for exploring new chemical entities and novel synthetic methodologies.

Basic Information

Product Name	Methyl 1-Tosyl-1H-Pyrrolo[3,2-B]Pyridine-2-Carboxylate
CAS No.	952182-32-0
Molecular Formula	C17H16N2O4S
Molecular Weight	344.39 g/mol
Synonyms	Methyl 1-(4-methylphenyl)sulfonyl-1H-pyrrolo[3,2-b]pyridine-2-carboxylate; 1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid, 1-[(4-methylphenyl)sulfonyl]-, methyl ester; Methyl 1-tosyl-1H-pyrrolo[3,2-b]pyridine-2-carboxylate; 952182-32-0; 1-Tosyl-1H-pyrrolo[3,2-b]pyridine-2-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 1-Tosyl-1H-Pyrrolo[3,2-B]Pyridine-2-Carboxylate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, meeting the stringent requirements of pharmaceutical R&D. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant quality management standards to support our global clientele in their regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.