Description

Methyl 5-Chloro 1-Tosyl-1H-Pyrrolo[2,3-B]Pyridine-3-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its specific pyrrolopyridine core structure. This compound is of significant value for its role as a critical building block in the synthesis of complex, biologically active molecules, particularly in medicinal chemistry. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, including kinase inhibitors and other targeted small-molecule drugs.

Application

This specialized intermediate serves as a key precursor in several high-value synthetic pathways. Its primary applications include:

• Pharmaceutical Research & Development: As a crucial scaffold for synthesizing potential drug candidates targeting various disease pathways.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization processes to develop new active pharmaceutical ingredients (APIs).
• Kinase Inhibitor Synthesis: The pyrrolopyridine structure makes it a valuable intermediate for creating compounds that modulate kinase activity, relevant in oncology and inflammatory diseases.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations (CROs/CMOs) for custom synthesis and scale-up projects.
• Academic Research: Utilized in university and institutional labs for exploratory synthetic chemistry and novel heterocycle development.

Basic Information

Product Name	Methyl 5-Chloro 1-Tosyl-1H-Pyrrolo[2,3-B]Pyridine-3-Carboxylate
CAS No.	952182-24-0
Molecular Formula	C17H13ClN2O4S
Molecular Weight	376.81 g/mol
Synonyms	Methyl 5-chloro-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridine-3-carboxylate; 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 5-chloro-1-[(4-methylphenyl)sulfonyl]-, methyl ester; 5-Chloro-1-tosyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester; Methyl 5-chloro-1-tosyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylate; 952182-24-0; 5-Chloro-1-tosyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylate methyl ester
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive pharmaceutical R&D. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The container should be kept in a well-ventilated area and protected from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.