Description

Methyl 6-(Trifluoromethyl)-1H-Pyrrolo[2,3-B]Pyridine-3-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a fused pyrrolopyridine core substituted with a trifluoromethyl group. This compound is of significant commercial value for its role as a critical building block in the synthesis of novel, biologically active molecules. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of small-molecule therapeutics, particularly within oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor for the development of novel active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies and lead optimization programs due to its privileged heterocyclic scaffold.
• Kinase Inhibitor Synthesis: The pyrrolopyridine structure is a common motif in kinase inhibitors, making this compound valuable for developing potential anticancer agents.
• Agrochemical Research: Employed in the research and development of new agrochemicals, where the trifluoromethyl group can enhance biological activity and metabolic stability.
• Material Science: Investigated as a building block for specialty chemicals and functional materials, including organic electronic components.

Basic Information

Product Name	Methyl 6-(Trifluoromethyl)-1H-Pyrrolo[2,3-B]Pyridine-3-Carboxylate
CAS No.	952182-21-7
Molecular Formula	C10H7F3N2O2
Molecular Weight	244.17 g/mol
Synonyms	Methyl 6-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylate; 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 6-(trifluoromethyl)-, methyl ester; 6-(Trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester; Methyl 6-trifluoromethyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylate
EINECS	Contact for details

Quality Control

Our Methyl 6-(Trifluoromethyl)-1H-Pyrrolo[2,3-B]Pyridine-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong acids, bases, and oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.