Description

1H-Pyrrolo[2,3-B]Pyridine-2-Carboxylic Acid, 6-(Trifluoromethyl)-, Methyl Ester is a high-value, multi-functional heterocyclic building block characterized by its pyrrolopyridine core and trifluoromethyl substituent. This compound matters for its critical role in modern medicinal chemistry, where it serves as a privileged scaffold for designing novel bioactive molecules. Pharmaceutical and agrochemical R&D teams need this intermediate to develop new active ingredients targeting a range of therapeutic areas and crop protection solutions.

Application

• Pharmaceutical Intermediate: A key synthon for the development of kinase inhibitors, particularly in oncology research, leveraging the pyrrolopyridine scaffold's ability to mimic purine bases.
• Agrochemical Synthesis: Used in constructing advanced active ingredients for crop protection, where the trifluoromethyl group enhances lipophilicity and metabolic stability.
• Material Science Research: Serves as a precursor for organic electronic materials and ligands in catalytic systems due to its rigid, conjugated structure.
• Chemical Biology Probes: Employed in the synthesis of tool compounds and fluorescent tags for studying biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for bespoke synthesis projects requiring complex fluorinated heterocycles.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine-2-Carboxylic Acid, 6-(Trifluoromethyl)-, Methyl Ester
CAS No.	952182-20-6
Molecular Formula	C10H7F3N2O2
Molecular Weight	244.17 g/mol
Synonyms	Methyl 6-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylate; 6-(Trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid methyl ester; 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, 6-(trifluoromethyl)-, methyl ester; 952182-20-6; Methyl 6-trifluoromethyl-1H-pyrrolo[2,3-b]pyridine-2-carboxylate; 6-Trifluoromethyl-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine-2-Carboxylic Acid, 6-(Trifluoromethyl)-, Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and structural identity suitable for advanced synthetic applications. Certificates of Analysis (COA) with full traceability are provided for every shipment, and we support compliance with relevant regulatory frameworks for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.